대한소화기학회로고
 
 
 
Author Soo-Young Na and Seung-Jae Myung
Place of duty Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Title Obesity and Colorectal Cancer
Publicationinfo The Korean Journal of Gastroenterology 2012 Jan; 059(01): 16-26.
Key_word Obesity; Colorectal neoplasms; Colorectal adenoma
Full-Text
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Obesity worldwide is constantly increasing. Obesity acts as an independent significant risk factor for malignant tumors of various organs including colorectal cancer. Visceral adipose tissue is physiologically more important than subcutaneous adipose tissue. The relative risk of colorectal cancer of obese patients is about 1.5 times higher than the normal-weight individuals, and obesity is also associated with premalignant colorectal adenoma. The colorectal cancer incidence of obese patients has gender-specific and site-specific characteristics that it is higher in men than women and in the colon than rectum. Obesity acts as a risk factor of colorectal carcinogenesis by several mechanisms. Isulin, insulin-like growth factor, leptin, adiponectin, microbiome, and cytokines of chronic inflammation etc. have been understood as its potential mechanisms. In addition, obesity in patients with colorectal cancer negatively affects the disease progression and response of chemotherapy. Although the evidence is not clear yet, there are some reports that weight loss as well as life-modification such as dietary change and physical activity can reduce the risk of colorectal cancer. It is very important knowledge in the point that obesity is a potentially modifiable risk factor that can alter the incidence and outcome of the colorectal cancer. (Korean J Gastroenterol 2012;59: 3-26)
저 자 나수영, 명승재
소 속 울산대학교 의과대학 서울아산병원 내과학교실
제 목 비만과 대장암
Copyright©2008 The Korean Society of Gastroenterlogy. All Rights Reserved.
Room 305, 31 Seolleung-ro 86 gil, Gangnam-gu, Seoul, 135-839, Korea
TEL:+82-2-538-0627 | FAX:+82-2-538-0635 | E-MAIL:gastrokorea@kams.or.kr