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Author 여말희 ( Mar Ie Yeo ) , 함기백 ( Ki Baik Hahm )
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Title Helicobacter pylori 연구동향 및 전망: Helicobacter pylori에 의한 위질환 발생의 분자생물 기전
Publicationinfo Korean J Gastroenterol 2005 Sep; 046(03): 181-188.
Key_word Helicobacter pylori, Gastric carcinogenesis, CagA, VacA, Epithelial cell signaling
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Helicobacter pylori (H. pylori) causes chronic gastritis in human stomach, a minority of which progress to peptic ulcer disease, atrophic gastritis, or gastric malignancies. Clinical outcomes of H. pylori infection has been shown to depend on the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions. This review provides an update on the molecular pathogenesis of H. pylori infection, focused on H. pylori virulence factors, H. pylori-gastric epithelium interactions, and modulation of host cell signaling. Understanding of H. pylori molecular pathogenic mechanism will facilitate the development of novel treatment strategies for eradication of the bacterium and prevention of H. pylori-induced gastropathy. (Korean J Gastroenterol 2005;46: 181-188)
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